When a child is sick and has to stay in the hospital it affects the whole family. One of the most common problems is not having enough money for hospital bills, medicine, traveling and some parents have to take time off from work making the situation even worse. Some parents can’t afford gifts for their children at Christmas.
Christmas time is a special time for Alicia and her family. So every year, to carry on the tradition that Alicia started, Alicia’s family and friends bring toys to the hospitals that help children. They try to bring enough toys so that the children in the hospital will have toys for Christmas but also enough so that the brothers and sisters can have a special gift as well.
Just One More Day for Love, Hope & a Cure
A searchable blog on DIPG research, DIPG news, recent publications, DIPG Foundations, DIPG researchers, clinical trials as well as other issues relating to Diffuse Intrinsic Pontine Tumors- both Diffuse Intrinsic Pontine Gliomas (DIPGs) and Atypical Pontine Lesions (APLs).
Sunday, December 6, 2015
Holiday Toy Drive ~ In memory of Alicia Marie Martin
Sunday, October 27, 2013
Holiday Toy Drive ~ In memory of Alicia Martin
Thursday, May 30, 2013
DIPG in Adolescents- Presentation and Outcomes
The 2013 abstract statistics are amazing. There were 5306 abstracts submitted from 75 countries. Of those, 2720 were accepted for presentation at the meeting and another 2034 were additionally accepted for ePublication. There were 172 abstracts submitted in the area of CNS Tumors and 81 in the field Pediatric Oncology.
One of those CNS abstracts happen to be on DIPGs!
Abstract: Diffuse intrinsic pontine gliomas (DIPG) in adolescents can have different prsentation but similar outcomes compared to middle childhood
Insitutions: NIH and Lurie Children's Hopsital of Chicago
Authors: Kathy Warren, Elad Jacoby and Jason Fangusaro
In this study 46 children between the ages 10-20 years of age (median 13) were identified. There was a female to male ratio of 1:0.77.
Symptoms: headache (39%); double vision (27%); cranial nerve issues (27%); dizziness (25%)
Two were incidental
Onset of Symptoms to Diagnosis: 2 days to 5 years (only 9 had symtoms less than 2 weeks)
Radiation: 39/42 patients had radation; 36% did not improve or got worse during riadation: 63% remained on steroids at the end of radation
Time to Progression: (n-32 for data available) 8 months median with a range of 2 months- 2.5 years; 2 alive and 1 in active treatment at time of abstract submission
Conclusion: Adolescents are more like kids than adults with diffuse intrinsic pontine lesions with similarly abysmal survival stats.
Diffuse intrinsic pontine gliomas (DIPG) in adolescents can have different prsentation but similar outcomes compared to middle childhood
Monday, May 27, 2013
Prenatal DIPG- a case report!
In this situation a 33 year female who had previously delivered 3 children without complications had an ultrasound at 33 weeks gestation. Unfortunately the ultrasound revealed a markedly enlarged head of a size more than 40 weeks but with an abdominal circumference and femur length of 33 weeks. There was also triventricular hydrocephalus without evidence of spina bifida.
A fetal MRI was then obtrained which showed a mass with the epicenter in the pons extending into the midbrain, medulla and cerebellar peduncles. The expansile mass had poor margins. There was severe hydrocephalus. No abnormalities were seen outside the brain. A diagnosis of diffuse pontine glioma was made.
The chid was delivered at 36 weeks, 4 days becaue of the big head and had Apgar scores of 7 and 9. A repeat MRI was preformed and confirmed the prior findings. The boy underwent placement of an extraventricular drain because of signs of increased intracranial pressure. The child died from respiratory failure at day 3.
At autospy the lesions was found to be primarily an infiltrative anaplastic oliogdendroglioma with areas of astroctyoma grade IV differentiation.
Although I have posted on neonatal tumors in the past (click here for prior blog post), the rarity of brainstem lesions in the neonatal period makes it difficult to know exactly what to do. Ther have been a few cases that have done well in the very young. There are other resports of the typically horrendous course of DIPG in the neonatal period. As researchers attempt to understand more about DIPG, this case adds to the library of knowledge regarding DIPG. The authors sugggest that autopsy studies should be strongly encouraged to learn more about this atypical situation. I would add that perhaps including this in the DIPG registry would also be helpful.
Prenatal MRI characterization of brainstem glioma
in Pediatric Radiology
Spontaneous regression of a diffuse brainstem lesion in the neonate. Report of two cases and review of the literature
Diffuse intrinsic brainstem tumors in neonates. Report of two case.