Just One More Day has teamed up with Kids V Cancer and Candlelighters Childhood Cancer Foundation in launching a petition for Gold Ribbon Awareness with a goal of a million signatures!
Earlier this year, Candlelighters Childhood Cancer Foundation unveiled the first product to have the gold ribbon for childhood cancer awareness- Jel Sert's Fla-Vor-Ice
In addition to Candlelighters, Jel Sert, also helps brain tumor researcher at Children's Memorial Hospital in Chicago through Reid's Lemon Aid.
This petition is not only to gain awareness but also to thank/recognize the first gold ribbon product. The hope is that overwhelming support of this can be used to convince other companies to consider a gold ribbon on their products.
In addition to signing the petition, one can write or call JelSert for their support of our kids-http://www.jelsert.com/Contact-Us/
1-800-323-2592
Please feel free to pass this one to your friends.
Monday, August 3, 2009
Tuesday, July 21, 2009
DIPG Dialogue
Introduction:
Dr. David Zagzag is an Associate Professor of Pathology and Neurosurgery, the Director of Microvascular and Molecular Neuro-Oncology Laboratory, and the Director of the Human Brain Tumor Bank at NYU Medical Center. His research and clinical interests include the pathology of nervous system, mechanisms of cerebral vasculogenesis and angiogenesis.
Questions & Answers:
What is a Brain Bank?
A brain tumor bank serves as a repository for tissues. These tissues are preserved in our bank by freezing or by fixation in different fixatives. Freezing and fixation help to assure that the tissues are safeguarded until needed for investigations.
Approximately how many brain tumor specimens do you have?
We currently have approximately 500 brain tumor specimens in our tumor bank.
How do you get these specimens- from surgery or from autopsy?
The specimens in the tumor bank are acquired from both surgery and autopsy.
Do you have any pediatric DIPG specimens?
We have specimens from approximately 250 pediatric brain tumor patients in our tumor bank. This includes approximately 15 pediatric patients diagnosed with DIPG.
What do you hope to do with these specimens?
We use these specimens to perform investigations into the pathogenesis of brain tumors. Our goal is to use the collected information to develop diagnostic and prognostic methods that can be translated into the clinic for therapeutic use in patients.
Is using the bank only open to those associated with NYU?
No, use of the brain tumor bank is not limited to those associated with NYU, investigators from any institution are welcome to request specimens from our bank.
Do you know of other brain banks for pediatric brain tumors?
Yes, though limited in number, other pediatric brain tumor banks have been established in universities, hospitals, and other medical institutions around the nation.
This endeavor is a team effort with Pediatric Neurosurgeons Drs. Jeffrey Wisoff, Howard Weiner and David Harter, and Pediatric Neurooncologists Drs. Jeffrey Allen, Sharon Gardner and Matthias Karajannis.
Dr. David Zagzag is an Associate Professor of Pathology and Neurosurgery, the Director of Microvascular and Molecular Neuro-Oncology Laboratory, and the Director of the Human Brain Tumor Bank at NYU Medical Center. His research and clinical interests include the pathology of nervous system, mechanisms of cerebral vasculogenesis and angiogenesis.
Questions & Answers:
What is a Brain Bank?
A brain tumor bank serves as a repository for tissues. These tissues are preserved in our bank by freezing or by fixation in different fixatives. Freezing and fixation help to assure that the tissues are safeguarded until needed for investigations.
Approximately how many brain tumor specimens do you have?
We currently have approximately 500 brain tumor specimens in our tumor bank.
How do you get these specimens- from surgery or from autopsy?
The specimens in the tumor bank are acquired from both surgery and autopsy.
Do you have any pediatric DIPG specimens?
We have specimens from approximately 250 pediatric brain tumor patients in our tumor bank. This includes approximately 15 pediatric patients diagnosed with DIPG.
What do you hope to do with these specimens?
We use these specimens to perform investigations into the pathogenesis of brain tumors. Our goal is to use the collected information to develop diagnostic and prognostic methods that can be translated into the clinic for therapeutic use in patients.
Is using the bank only open to those associated with NYU?
No, use of the brain tumor bank is not limited to those associated with NYU, investigators from any institution are welcome to request specimens from our bank.
Do you know of other brain banks for pediatric brain tumors?
Yes, though limited in number, other pediatric brain tumor banks have been established in universities, hospitals, and other medical institutions around the nation.
This endeavor is a team effort with Pediatric Neurosurgeons Drs. Jeffrey Wisoff, Howard Weiner and David Harter, and Pediatric Neurooncologists Drs. Jeffrey Allen, Sharon Gardner and Matthias Karajannis.
Saturday, July 18, 2009
DIPG Digest
DIPG News brought to you by:
Just One More Day for Love, Hope & a Cure
http://www.justonemoreday.org/
July 18, 2009
Please submit information you feel will be helpful to DIPG families to JustOneMoreDay@cfl.rr.com subject: DIPG Digest
Copyright 2008 - 2009 Just One More Day for Love, Hope & a Cure, Inc. Allrights reserved. The materials and links provided on this site have beenprepared for information purposes only and should not be construed as advice oropinions on any specific facts or circumstances. Medical research concerningdisease and treatments is an ongoing process. Readers should not act upon thisinformation, but should obtain advice from physicians, medical institutions orother professionals, as appropriate.
Just One More Day for Love, Hope & a Cure
http://www.justonemoreday.org/
July 18, 2009
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Medical News
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J Neurooncol. 2009 Jul 8.
“There is a need for relevant brainstem tumor models that can be used to test new therapeutic agents and delivery systems in pre-clinical studies. We report the development of a brainstem-tumor model in rats and the application of bioluminescence imaging (BLI) for monitoring tumor growth and response to therapy as part of this model……This model is well suited for pre-clinical testing of therapeutics that are being considered for treatment of patients with brainstem tumors.”
Childs Nerv Syst. 2009 May;25(5):527-33. Epub 2009 Jan 13
“This study demonstrates a robust rodent model with the ability to monitor brainstem tumor growth and response to chemotherapeutic agents.”
Expert Opin Ther Targets. 2009 Apr;13(4):455-68
“It should be kept in mind though that tumours can develop escape mechanisms. In particular invasive cells, which migrate away from the highly vascularized tumour core, are not targeted by anti-angiogenic therapies. In our opinion, the future of anti-angiogenic therapy will rely on a combination strategy including chemotherapy and drugs that target invasive glioma cells.”
Cancer Res. 2009 Jul 15;69(14):5987-95. Epub 2009 Jun 30
“this study describes a new high-throughput technique to generate clinically relevant tyrosine kinase activity profiles as has been shown here for pediatric brain tumors. In the era of a rapidly increasing number of small-molecule inhibitors, this approach will enable us to rapidly identify new potential targets in a broad range of human malignancies.”
Curr Stem Cell Res Ther. 2009 Dec 1. [Epub ahead of print]
“In this review, we describe the issues surrounding the identification and characterization of BTSC, the molecular biology of BTSC for different pediatric brain tumors, and suggest future avenues for the development of treatments for this devastating disease.”
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For past issues of DIPG Digest please visit
Please submit information you feel will be helpful to DIPG families to JustOneMoreDay@cfl.rr.com subject: DIPG Digest
Copyright 2008 - 2009 Just One More Day for Love, Hope & a Cure, Inc. Allrights reserved. The materials and links provided on this site have beenprepared for information purposes only and should not be construed as advice oropinions on any specific facts or circumstances. Medical research concerningdisease and treatments is an ongoing process. Readers should not act upon thisinformation, but should obtain advice from physicians, medical institutions orother professionals, as appropriate.
Saturday, June 13, 2009
DIPG Digest
DIPG News brought to you by:
Just One More Day for Love, Hope & a Cure
http://www.justonemoreday.org/
June 13, 2009
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Medical News
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Treatment of diffuse intrinsic brainstem gliomas: failed approaches and future strategies. :“The discussion includes a rationale for stereotactic biopsies as well as possible therapeutic options of local chemotherapy in these lesions.”
Neurological grading, survival, MR imaging, and histological evaluation in the rat brainstem glioma model. :“Local chemotherapy in the brainstem glioma model showed significant efficacy for histological changes and survival. Our neurological grading enables quantification of drug and tumor-related morbidity as an important factor for functional performance during therapy.”
Diffuse pontine glioma in Jordan and impact of up-front prognosis disclosure with parents and families. :“Contrary to the common belief, our study showed that do not resuscitate should be addressed in Muslim patients with high-risk malignancies. We also found that diffuse pontine glioma warrants further study in developing countries.”
Continual reassessment method vs. traditional empirically based design: modifications motivated by Phase I trials in pediatric oncology by the Pediatric Brain Tumor Consortium. :“Compared to the TM, our simulations indicate that the modified version of CRM is more accurate, exposes fewer patients to potentially toxic doses, and tends to require fewer patients. "
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Medical Updates
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DIPG Conference Memorial “Alicia Pueyo” Workshop Research on Pontine Gliomas held in Barcelona Spain,on February 26th 2009Conference video is now available at Just One More Day
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Foundation News
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2nd Annual Smiles For Sophie Forever Birthday Bash and Dash5K and 1 Mile Run/WalkSaturday, July 4, 2009 at 9:00 a.m.Walker Road Park31621 Walker RoadAvon Lake, OH 44012
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Just One More Day for Love, Hope & a Cure
http://www.justonemoreday.org/
June 13, 2009
__________________________________________
Medical News
__________________________________________
Treatment of diffuse intrinsic brainstem gliomas: failed approaches and future strategies. :“The discussion includes a rationale for stereotactic biopsies as well as possible therapeutic options of local chemotherapy in these lesions.”
Neurological grading, survival, MR imaging, and histological evaluation in the rat brainstem glioma model. :“Local chemotherapy in the brainstem glioma model showed significant efficacy for histological changes and survival. Our neurological grading enables quantification of drug and tumor-related morbidity as an important factor for functional performance during therapy.”
Diffuse pontine glioma in Jordan and impact of up-front prognosis disclosure with parents and families. :“Contrary to the common belief, our study showed that do not resuscitate should be addressed in Muslim patients with high-risk malignancies. We also found that diffuse pontine glioma warrants further study in developing countries.”
Continual reassessment method vs. traditional empirically based design: modifications motivated by Phase I trials in pediatric oncology by the Pediatric Brain Tumor Consortium. :“Compared to the TM, our simulations indicate that the modified version of CRM is more accurate, exposes fewer patients to potentially toxic doses, and tends to require fewer patients. "
___________________________________________
Medical Updates
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The FDA Biopsy MeetingOn April 27, 2009, the Committee met to discuss the scientific and ethical issues involved in obtaining and using brain biopsy specimens to evaluate gene expression patterns in children with diffuse pontine gliomas.The slides from this meeting can be viewed here
DIPG Conference Memorial “Alicia Pueyo” Workshop Research on Pontine Gliomas held in Barcelona Spain,on February 26th 2009Conference video is now available at Just One More Day
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Foundation News
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DIPG Dialogue - Talking with the ExpertsJust One More Day is starting a new feature called DIPG Dialogue which will contain interviews with researchers, physicians and other advocates in the DIPG community.
2nd Annual Smiles For Sophie Forever Birthday Bash and Dash5K and 1 Mile Run/WalkSaturday, July 4, 2009 at 9:00 a.m.Walker Road Park31621 Walker RoadAvon Lake, OH 44012
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Please submit information you feel will be helpful to DIPG families to JustOneMoreDay@cfl.rr.com subject: DIPG Digest
Copyright 2008 - 2009 Just One More Day for Love, Hope & a Cure, Inc. Allrights reserved. The materials and links provided on this site have beenprepared for information purposes only and should not be construed as advice oropinions on any specific facts or circumstances. Medical research concerningdisease and treatments is an ongoing process. Readers should not act upon thisinformation, but should obtain advice from physicians, medical institutions orother professionals, as appropriate.
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