DIPG/DIPT Discussion

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A searchable blog on DIPG research, DIPG news, recent publications, DIPG Foundations, DIPG researchers, clinical trials as well as other issues relating to Diffuse Intrinsic Pontine Tumors- both Diffuse Intrinsic Pontine Gliomas (DIPGs) and Atypical Pontine Lesions (APLs).

For parents, family and friends of children with DIPG looking for information and connection to others dealing with DIPG please check the buttons on the right hand side for resources.

Wednesday, August 26, 2009

DIPG Digest

*****Medical News*****

Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. I. class III beta-tubulin.
J Cell Physiol. 2009 Jul 31
“This minireview focuses on microtubules and tubulin as emerging targets in potential therapy of GBM using a new class of betaIII-tubulin-targeted drugs…”

Targeting rat brainstem glioma using human neural stem cells and human mesenchymal stem cells.
Clin Cancer Res. 2009 Aug 1;15(15):4925-34. Epub 2009 Jul 28
“Genetically engineered NSCs show therapeutic efficacy against brainstem gliomas.”

Virotherapy against malignant glioma stem cells.
Cancer Lett. 2009 Jul 28
“In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.”

Dendritic cell vaccines for cancer stem cells.
Methods Mol Biol. 2009;568:233-47
“Our results suggest that only DC vaccination against neurospheres can restrain the growth of a highly infiltrating and aggressive model of glioma and may have implications for the design of novel, more effective immunotherapy trials for malignant glioma and possibly other malignancies.”

Paediatric high and low grade glioma: the impact of tumour biology on current and future therapy.
Br J Neurosurg. 2009 Aug;23(4):351-63
“Brainstem glioma remains a tumour with a dismal prognosis but relatively little is known about the underlying biology and progress will require a concerted effort to collect tissue by biopsy and autopsy to allow appropriate analysis to identify and validate targets. A new era of molecular based therapies offers the promise of major benefits in the management of paediatric glioma but translating this promise into reality will require further understanding of the biology driving these tumours.”

Cediranib: profile of a novel anti-angiogenic agent in patients with glioblastoma.
Expert Opin Investig Drugs. 2009 Aug 12
“Cediranib is an effective drug in patients with glioblastoma, acting through inhibition of angiogenesis and normalization of tumor vasculature. Reduction of vasogenic brain edema is a key component of its treatment effect in this patient population. The primary side effects of cediranib include fatigue, diarrhea and hypertension.”


September is Childhood Cancer Awareness Month

Team Unite Awareness Flyer http://teamunite.net/pdf/TeamUnite_SEPTEMBER.pdf
Team Unite Awareness Gear http://www.cafepress.com/teamunite/6830914

September 12, 2009

Tyler's Treehouse 5K & 1-Mile Fun Run/Walk
"Spirit Runners" are always appreciated!
Olde Georgetowne Swim Club, Charlotte, NC

Just One More Day
Celebrating Childhood Cancer Awareness Day along with the life of Alicia Martin
Sonoma Park
2922 Sonoma Way, Viera, Florida

Love, Chloe Foundation
The foundation will be at Rolling Hills Zoo all day long to sell monkeysWe have the cutest monkeys that we are selling at the zoo. We will also have shirts, hats and bracelets

September 13, 2009

Aimee’s Army
The annual Aimee Dickey walk for childhood cancer/DIPG (brain tumors)
Nay Aug Park, Scranton, PA

Just One More Day
The Brianna Sharp Golf Outing
Country Lake Golf Course
Naperville, Illinois

September 19, 2009

Love, Chloe Foundation
2nd Annual Kickball Jam. Games start at 9am. Teams must be registeredby Tuesday, September 1.


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