DIPG Digest

April 26, 2009


Medical News

Pediatric brain tumors: mutations of two dioxygenases (hABH2 and hABH3) that directly repair alkylation damage. : http://www.ncbi.nlm.nih.gov/pubmed/19290481?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


Turning cancer stem cells inside-out: an exploration of glioma stem cell signaling pathways. Free Full Text- http://www.jbc.org/cgi/reprint/R900013200v1

Tumour vaccine approaches for CNS malignancies: progress to date. : http://www.ncbi.nlm.nih.gov/pubmed/19275269?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


New Trial

Vaccine Therapy in Treating Young Patients With Newly Diagnosed or Recurrent Glioma
A Pilot Study to Evaluate the Effects of Vaccinations With HLA-A2-Restricted Glioma Antigen-Peptides in Combination With Poly-ICLC for Children With Newly Diagnosed Malignant or Intrinsic Brain Stem Gliomas (BSG) or Incompletely Resected Non-Brainstem High-Grade Gliomas (HGG) or Recurrent Unresectable Low-Grade Gliomas (LGG)
http://www.clinicaltrials.gov/ct2/show/NCT00862199?term=vaccine+brain+tumor+children&rank=6

Convection Enhanced Delivery of IL13-PE38QQR in Patients with DIBG
*The following information was copied directly from http://www.clinicaltrials.gov/ . It is, however, our understanding that the study is not actually open as of this date.An Open Label Dose Escalation Safety Study of Convection-Enhanced Delivery of IL13-PE38QQR in Patients With Progressive Pediatric Diffuse Infiltrating Brainstem Glioma and Supratentorial High-Grade Glioma
This study is currently recruiting participants. *
Verified by National Institutes of Health Clinical Center (CC), March 2009First Received: April 10, 2009 No Changes Posted
Sponsored by:National Institute of Neurological Disorders and Stroke (NINDS)
http://clinicaltrials.gov/ct2/show/NCT00880061?term=convection+enhanced+delivery&rank=1


FDA to Discuss DIPG Biopsies

Date and Time of Meeting:
April 27, 2009, from 8 a.m. to 6 p.m.

Date and Time of the Open Public Hearing:
April 27, 2009, between approximately 1 p.m. and 2 p.m.

Address of Meeting:
Washington DC North/Gaithersburg Hilton,
620 Perry Pkwy.,
Gaithersburg, MD 20877.

Agenda:
On April 27, 2009, the Committee will meet to discuss the scientific and ethical issues involved in obtaining and using brain biopsy specimens to evaluate gene expression patterns in children with diffuse pontine gliomas.
http://www.fda.gov/oc/advisory/default.htm


Foundations News

Reflections of Grace -- Race For Grace Draws Huge Turnout http://www.wpxi.com/news/19036532/detail.html

Just One More Day – UmbrELLA of Hope Family Fun Walk
Saturday, May 16, 2009
Lakefront Park in Prior Lake MN
http://www.umbrellaofhope.com/Pages/Home.aspx



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