DIPG Digest

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Just One More Day for Love, Hope & a Cure
http://www.justonemoreday.org/

July 18, 2009

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Medical News
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A human brainstem glioma xenograft model enabled for bioluminescence imaging.

J Neurooncol. 2009 Jul 8.

“There is a need for relevant brainstem tumor models that can be used to test new therapeutic agents and delivery systems in pre-clinical studies. We report the development of a brainstem-tumor model in rats and the application of bioluminescence imaging (BLI) for monitoring tumor growth and response to therapy as part of this model……This model is well suited for pre-clinical testing of therapeutics that are being considered for treatment of patients with brainstem tumors.”

An experimental brainstem tumor model using in vivo bioluminescence imaging in rat.

Childs Nerv Syst. 2009 May;25(5):527-33. Epub 2009 Jan 13

“This study demonstrates a robust rodent model with the ability to monitor brainstem tumor growth and response to chemotherapeutic agents.”

Anti-VEGF therapies for malignant glioma: treatment effects and escape mechanisms.

Expert Opin Ther Targets. 2009 Apr;13(4):455-68

“It should be kept in mind though that tumours can develop escape mechanisms. In particular invasive cells, which migrate away from the highly vascularized tumour core, are not targeted by anti-angiogenic therapies. In our opinion, the future of anti-angiogenic therapy will rely on a combination strategy including chemotherapy and drugs that target invasive glioma cells.”

Kinome profiling in pediatric brain tumors as a new approach for target discovery

Cancer Res. 2009 Jul 15;69(14):5987-95. Epub 2009 Jun 30

“this study describes a new high-throughput technique to generate clinically relevant tyrosine kinase activity profiles as has been shown here for pediatric brain tumors. In the era of a rapidly increasing number of small-molecule inhibitors, this approach will enable us to rapidly identify new potential targets in a broad range of human malignancies.”

Cancer Stem Cells in Pediatric Brain Tumors

Curr Stem Cell Res Ther. 2009 Dec 1. [Epub ahead of print]

“In this review, we describe the issues surrounding the identification and characterization of BTSC, the molecular biology of BTSC for different pediatric brain tumors, and suggest future avenues for the development of treatments for this devastating disease.”

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