Clinical Trials for the Newly Diagnosed Child with DIPG

A review of  www.clinicaltrials.gov was done on October 20, 2011 to identify which therapeutic trials are currently listed as open for the newly diagnosed child with DIPG.   The following is information on the ten (10) listed trials that were listed as accruing patients as well as one vaccine trial that is yet to open.  Clinicaltrials.gov seems to be often not be up to date on trial status.  If you have interest or questions it might be wise to contact the primary investigator.  Contact information is listed at the bottom of each clinical trial site.  Most US clinical trials for DIPG can be found with the key word “pontine glioma” but some are still listed under “brainstem glioma”. 

*Note- many, if not most clinical trials will not allow you to enter a trial if you have already started treatment. 

 

PDGFR Inhibitor Crenolanib in Children/Young Adults With Diffuse Intrinsic Pontine Glioma or Recurrent High-Grade Glioma

Phase 1
ligible age- 18 months- 21 years
Study Chair- Cynthia Wetmore
Location- St Jude (Memphis, TN)
http://clinicaltrial.gov/ct2/show/NCT01393912?term=pontine+glioma&recr=Open&rank=1

Molecularly Determined Treatment of Diffuse Intrinsic Pontine Glioma

Phase 2
Eligible age- 3-18 years
Study Chair- Mark Kieran
Location- when open up to 20 locations- only Boston open on 10/20/11
http://clinicaltrial.gov/ct2/show/NCT01182350?term=pontine+glioma&recr=Open&rank=3

Lenalidomide and Radiation Therapy in High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas 

Phase 1
Eligible age- 1-18 years
Location- NIH (Bethesda, MD)
http://clinicaltrial.gov/ct2/show/NCT01222754?term=pontine+glioma&recr=Open&rank=4


A Study of Bevacizumab Therapy in Patients With Newly Diagnosed High-Grade Gliomas and Diffuse Intrinsic Pontine Glioma 
Phase- not listed
Eligible age- 3-30 years
Study Chair- Maryam Fouladi
Location- Cincinnati and Chicago
http://clinicaltrial.gov/ct2/show/NCT00890786?term=pontine+glioma&recr=Open&rank=5

Cilengitide in Combination With Irradiation in Children With Diffuse Intrinsic Pontine Glioma 

Phase 1
Eligible age- 6 months-21 years
Study Chair. Pierre Leblond
Location- France
http://clinicaltrial.gov/ct2/show/NCT01165333?term=pontine+glioma&recr=Open&rank=7

Phase I Rindopepimut After Conventional Radiation in Children w/ Diffuse Intrinsic Pontine Gliomas 

Phase 1
Eligible age- 3 to 18
Study Chair- Paul Fisher
Location- Stanford (Palo Alto, CA)
http://clinicaltrial.gov/ct2/show/NCT01058850?term=pontine+glioma&recr=Open&rank=8

Vorinostat and Radiation Therapy Followed By Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Pontine Glioma 

Phase 1/2
Eligible age- 3 to 21 years
Study Chair- Jack Su
Location- COG trial- multiple locations
http://clinicaltrial.gov/ct2/show/NCT01189266?term=pontine+glioma&recr=Open&rank=11


Pilot Study of  Glioma Associated Antigen Vaccines in Conjunction With Poly-ICLC in Pediatric Gliomas
Phase- none listed (listed as a pilot)
Eligible age- 19 months – 20 years
Study Chair- Regina Jakacki
Location- Pittsburgh
http://clinicaltrial.gov/ct2/show/NCT01130077?term=pontine+glioma&recr=Open&rank=13

External Beam Radiation Therapy and Cetuximab Followed by Irinotecan and Cetuximab for Children and Young Adults With Newly Diagnosed Diffuse Pontine Tumors and High-Grade Astrocytomas

Phase
Eligible age-
Study Chair-
Location-
http://clinicaltrial.gov/ct2/show/NCT01012609?term=pontine+glioma&recr=Open&rank=15

Valproic Acid and Radiation Followed by Maintenance Valproic Acid and Bevacizumab in Children With High Grade Gliomas 
Phase 2
Eligible age- 3-21 years
Study Chair- Ira Dunkel
Location- POETIC study- several locations
http://clinicaltrial.gov/ct2/show/NCT00879437?term=brainstem+glioma&recr=Open&rank=9

 Not Yet Open-

Imiquimod/Brain Tumor Initiating Cell (BTIC) Vaccine in Brain Glioma 

Phase 1
Eligible age- 3 to 25 years
Study Chair- Christopher Moetel
Location- Minneapolis. MN
http://clinicaltrial.gov/ct2/show/NCT01400672?term=pontine+glioma&recr=Open&rank=6